Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG. - ENSTA Paris - École nationale supérieure de techniques avancées Paris Accéder directement au contenu
Article Dans Une Revue Genomics Année : 1992

Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.

L G Wright
  • Fonction : Auteur
B de Gouyon
  • Fonction : Auteur
V Lauthier
  • Fonction : Auteur
L M Silver
  • Fonction : Auteur
H M Cann
  • Fonction : Auteur
R S Spielman
  • Fonction : Auteur

Résumé

Human homologues of mouse t-complex genes have been cloned and localized physically to chromosome 6p or 6q. TCP1, TCP10, and PLG are human homologues of genes located in the proximal portion of the t-complex on mouse chromosome 17. We present here results of genetic mapping of these human t-complex homologues previously localized to 6q25-q27, 6q21-q27, and 6q26-q27, respectively, by physical techniques. TCP1 and PLG do not recombine with each other and are separated from TCP10 by about 15 cM, while the corresponding mouse genes are no more than 4 cM apart. Genetic mapping with markers well localized cytogenetically places TCP1 and PLG proximal to TCP10 and localizes the latter to the cytogenetic band 6q27. It is likely that the organization of human t-complex homologues on 6q is similar to that of t haplotypes rather than that of wildtype murine chromosome 17.
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Dates et versions

hal-01160689 , version 1 (06-06-2015)

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  • HAL Id : hal-01160689 , version 1
  • PUBMED : 1572657

Citer

H Blanché, L G Wright, Gilles Vergnaud, B de Gouyon, V Lauthier, et al.. Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.. Genomics, 1992, 12 (4), pp.826-8. ⟨hal-01160689⟩
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