Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson’s Disease (PSYCHO-STIM II)

Mathilde Boussac (1) , Christophe Arbus (2) , Helene Klinger (3) , Alexandre Eusebio (4, 5) , Elodie Hainque (6, 7) , Jean Christophe Corvol (8, 6) , Olivier Rascol (1, 9) , Vanessa Rousseau (9, 10) , Estelle Harroch (9, 10) , Charlotte Scotto D’apollonia (9, 10) , Aurélie Croiset (11) , Fabienne Ory-Magne (1, 9, 10) , Amaury de Barros (1) , Margherita Fabbri (1, 9, 10) , Caroline Moreau (12) , Anne-Sophie Rolland (12) , Isabelle Benatru (13) , Mathieu Anheim (14, 15) , Ana-Raquel Marques (16, 17) , David Maltête (18) , Sophie Drapier (19, 20) , Béchir Jarraya (21, 22) , Cécile Hubsch (23) , Dominique Guehl (24) , Mylène Meyer (25) , Tiphaine Rouaud (26) , Bruno Giordana (27) , Mélissa Tir (28) , David Devos (12) , Christine Brefel-Courbon (1, 9)

1 ToNIC - Toulouse NeuroImaging Center
2 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
3 HCL - Hospices Civils de Lyon, Departement de Neurologie
4 TIMONE - Hôpital de la Timone [CHU - APHM]
5 INT - Institut de Neurosciences de la Timone
6 CHU Pitié-Salpêtrière [AP-HP]
7 SU FM - Sorbonne Université - Faculté de Médecine
8 ICM - Institut du Cerveau = Paris Brain Institute
9 NeuroToul - Centre d’Excellence en Maladies Neurodégénératives
10 CIC - Biotherapie - Toulouse
11 CERPPS - Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé
12 LilNCog - Lille Neurosciences & Cognition - U 1172
13 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
14 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
15 Inserm U964 - CNRS UMR7104 - IGBMC - Centre for Integrative Biology - CBI
16 INP Clermont Auvergne - Institut national polytechnique Clermont Auvergne
17 IP - Institut Pascal
18 DC2N - Différenciation et communication neuronale et neuroendocrine
19 CIC - Centre d'Investigation Clinique [Rennes]
20 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
21 UNICOG-U992 - Neuroimagerie cognitive - Psychologie cognitive expérimentale
22 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
23 Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
24 CHU Bordeaux
25 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
26 Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
27 CHU Nice - Centre Hospitalier Universitaire de Nice
28 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559

BACKGROUND: Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) reduces symptoms in Parkinson’s disease (PD) patients with motor fluctuations. However, some patients may not feel ameliorated afterwards, despite an objective motor improvement. It is thus important to find new predictors of patients’ quality of life (QoL) amelioration after DBS-STN. We hypothesized that personality dimensions might affect QoL after DBS-STN. OBJECTIVE: To evaluate associations between personality dimensions and QoL improvement one year after DBS-STN. METHODS: DBS-STN-PD patients (n = 303) having answered the "Temperament and Character Inventory" (TCI) before surgery and the PDQ-39 before and one year after surgery were included, from the cohort study PREDI-STIM. Linear regression models were used to evaluate associations between TCI dimensions and change in PDQ-39 scores after DBS-STN. RESULTS: Novelty Seeking and Cooperativeness scores before surgery were positively associated with PDQ-39 scores improvement after DBS-STN (FDR-adjusted p <  0.01). Moreover, paradoxically unimproved patients with deterioration of their PDQ-39 scores after DBS-STN despite improvement of their MDS-UPDRS-IV scores had lower Cooperativeness scores, while paradoxically improved patients with amelioration of their PDQ-39 scores despite deterioration of their MDS-UPDRS-IV scores had higher Reward Dependence scores. CONCLUSION: Some presurgical personality dimensions were significantly associated with QoL amelioration and discrepancy between motor state and QoL changes after DBS-STN in PD. Educational programs before DBS-STN should take in account patient personality dimensions to better deal with their expectations.

Mots clés: Cooperativeness; DBS-STN; Parkinson’s disease; novelty seeking; quality of life; Cooperativeness

Domaines: Sciences du Vivant [q-bio]

Mathilde Boussac, Christophe Arbus, Helene Klinger, Alexandre Eusebio, Elodie Hainque, et al.. Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson’s Disease (PSYCHO-STIM II). Journal of Parkinson's disease, 2022, 12 (2), pp.699-711. ⟨10.3233/JPD-212883⟩. ⟨hal-03513907⟩