Disease reactivation after fingolimod cessation in Multiple Sclerosis patients with pregnancy desire: A retrospective study

Alix Callens (1, 2) , Soline Leblanc (3, 4) , Emmanuelle Le Page (1, 2) , Gilles Edan (1, 2) , Aurore Jourdain (5) , Marc Coustans (6) , Sandrine Wiertlewski (7, 8) , David Laplaud (9, 10, 8) , Dorothée Videt (11) , Francois Lallement (12) , Emmanuelle Leray (3, 13, 4) , Laure Michel (1, 2)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 CIC - Centre d'Investigation Clinique [Rennes]
3 ARENES - Arènes: politique, santé publique, environnement, médias
4 RSMS - Recherche sur les services et le management en santé
5 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
6 CHI Cornouaille [Quimper] - Centre Hospitalier Intercommunal de Cornouaille [Quimper]
7 CIC 0004 - Nantes - Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique
8 CHU Nantes - Centre Hospitalier Universitaire de Nantes
9 U1064 Inserm - CR2TI - Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
10 CIC Nantes - Centre d’Investigation Clinique de Nantes
11 CH Vannes
12 CHU de Saint-Brieuc
13 EHESP - École des Hautes Études en Santé Publique [EHESP]

Reactivation of Multiple Sclerosis (MS) activity has been described after fingolimod cessation. Because of its contra indication during pregnancy, switch towards lower efficacy treatments are frequent in MS patients with childbearing desire but expose them to a risk of disease reactivation. In this retrospective study including 44 women with MS, a significant increase of the median annualized relapse rate was found in the year following fingolimod discontinuation compared to the period before (p < 0.0001), and 57% of women experienced at least one relapse. When considering to start fingolimod, particular attention should be paid to women with a short-term pregnancy desire

Mots clés: Fingolimod-disease reactivation; Multiple Sclerosis; Pregnancy desire

Domaines: Santé publique et épidémiologie

Alix Callens, Soline Leblanc, Emmanuelle Le Page, Gilles Edan, Aurore Jourdain, et al.. Disease reactivation after fingolimod cessation in Multiple Sclerosis patients with pregnancy desire: A retrospective study. Multiple Sclerosis and Related Disorders, 2022, 66, pp.104066. ⟨10.1016/j.msard.2022.104066⟩. ⟨hal-03753568⟩