The long and short of membrane fission.

Aurélien Roux (1) , Bruno Antonny (2)

1 PCC - Physico-Chimie-Curie
2 IPMC - Institut de pharmacologie moléculaire et cellulaire

During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. Although it has been proposed that fission results from the constriction of the dynamin helix, new work by Bashkirov et al. (2008) and Pucadyil and Schmid (2008) unexpectedly shows that helix disassembly is also necessary for membrane fission.

Domaines: Biochimie, Biologie Moléculaire

Aurélien Roux, Bruno Antonny. The long and short of membrane fission.. Cell, 2008, 135 (7), pp.1163-5. ⟨10.1016/j.cell.2008.12.003⟩. ⟨hal-00418739⟩