Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. - Institut Curie Accéder directement au contenu
Article Dans Une Revue Journal of Cell Biology Année : 2010

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.

Résumé

Posttranslational glutamylation of tubulin is present on selected subsets of microtubules in cells. Although the modification is expected to contribute to the spatial and temporal organization of the cytoskeleton, hardly anything is known about its functional relevance. Here we demonstrate that glutamylation, and in particular the generation of long glutamate side chains, promotes the severing of microtubules. In human cells, the generation of long side chains induces spastin-dependent microtubule disassembly and, consistently, only microtubules modified by long glutamate side chains are efficiently severed by spastin in vitro. Our study reveals a novel control mechanism for microtubule mass and stability, which is of fundamental importance to cellular physiology and might have implications for diseases related to microtubule severing.
Fichier principal
Vignette du fichier
J_Cell_Biol-2010-Lacroix-945-54.pdf (6.53 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-00509804 , version 1 (18-11-2010)

Identifiants

Citer

Benjamin Lacroix, Juliette van Dijk, Nicholas D Gold, Julien Guizetti, Gudrun Aldrian-Herrada, et al.. Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.. Journal of Cell Biology, 2010, 189 (6), pp.945-54. ⟨10.1083/jcb.201001024⟩. ⟨hal-00509804⟩
157 Consultations
221 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More