The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. - Institut Curie Accéder directement au contenu
Article Dans Une Revue Nature Structural and Molecular Biology Année : 2012

The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.

Résumé

SUMOylation promotes targeting of HP1α to pericentric heterochromatin. Here we identify the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1α accumulation at this location. SENP7 interacts directly with HP1α, localizes at HP1-enriched pericentric domains and can deconjugate SUMOylated HP1α in vivo. Depletion of SENP7 delocalizes HP1α from pericentric heterochromatin without affecting H3K9me3 levels. We propose that following targeting of HP1α, a subsequent deSUMOylation event enables HP1α retention at these domains.
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Dates et versions

hal-00765968 , version 1 (17-12-2012)

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Christèle Maison, Kelly Romeo, Delphine Bailly, Marion Dubarry, Jean-Pierre Quivy, et al.. The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.. Nature Structural and Molecular Biology, 2012, 19 (4), pp.458-60. ⟨10.1038/nsmb.2244⟩. ⟨hal-00765968⟩
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