Synthesis and evaluation of substituted indolizines as peptidomimetics of RGD tripeptide sequence
Résumé
The synthesis of seven peptidomimetics of RGD is presented. The indolizine building block was obtained by condensation of allylglycine with dimethoxydihydrofuran followed by an intermolecular cyclisation. The bicyclic ring was functionalised with a carboxylic acid and a guanidinium appendage. The seven peptidomimetics were evaluated by cell-adhesion assays.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers produits par l'(les) auteur(s)
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