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Journal Articles Cell Reports Year : 2015

Cytoplasmic Control of Sense-Antisense mRNA Pairs

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Abstract

Transcriptome analyses have revealed that convergent gene transcription can produce many 3′-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3′-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3′-overlapping messengers or their impact on gene expression. Here, we demonstrate that the complementary tails of 3′-overlapping mRNAs can interact in the cytoplasm and promote post-transcriptional regulatory events including no-go decay (NGD) in Saccharomyces cerevisiae. Genome-wide experiments confirm that these messenger-interacting mRNAs (mimRNAs) form RNA duplexes in wild-type cells and thus have potential roles in modulating the mRNA levels of their convergent gene pattern under different growth conditions. We show that the post-transcriptional fate of hundreds of mimRNAs is controlled by Xrn1, revealing the extent to which this conserved 5′-3′ cytoplasmic exoribonuclease plays an unexpected but key role in the post-transcriptional control of convergent gene expression.
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Dates and versions

hal-01216461 , version 1 (16-10-2015)

Licence

Attribution - CC BY 4.0

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Flore Sinturel, Albertas Navickas, Maxime Wery, Marc Descrimes, Antonin Morillon, et al.. Cytoplasmic Control of Sense-Antisense mRNA Pairs. Cell Reports, 2015, 12 (11), pp.1853-1864. ⟨10.1016/j.celrep.2015.08.016⟩. ⟨hal-01216461⟩
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