“ One Ring to Bind Them All ”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition - Institut Curie Accéder directement au contenu
Article Dans Une Revue Journal of Nucleic Acids Année : 2010

“ One Ring to Bind Them All ”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition

Résumé

Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the "standard" B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. Stimulated by the pioneering studies on the cationic porphyrin TMPyP4 and the natural product telomestatin, follow-up studies have developed, rapidly leading to a large diversity of macrocyclic structures with remarkable-quadruplex binding properties and biological activities. In this review we summarize the current state of the art in detailing the three main categories of quadruplex-binding macrocycles described so far (telomestatin-like polyheteroarenes, porphyrins and derivatives, polyammonium cyclophanes), and in addressing both synthetic issues and biological aspects.

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Chimie
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Dates et versions

hal-02125700 , version 1 (10-10-2019)

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Citer

David Monchaud, Anton Granzhan, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, et al.. “ One Ring to Bind Them All ”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition. Journal of Nucleic Acids , 2010, 2010, pp.1-19. ⟨10.4061/2010/525862⟩. ⟨hal-02125700⟩
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