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Article Dans Une Revue Nature Immunology Année : 2018

Diversification of human plasmacytoid predendritic cells in response to a single stimulus

Pablo Vargas
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  • IdHAL : pvargas

Résumé

Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1+CD80-) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80+) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1+CD80+) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.

Domaines

Immunité innée
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Dates et versions

hal-02349815 , version 1 (05-11-2019)

Identifiants

Citer

Solana Alculumbre, Violaine Saint-André, Jérémy Di Domizio, Pablo Vargas, Philemon Sirven, et al.. Diversification of human plasmacytoid predendritic cells in response to a single stimulus. Nature Immunology, 2018, 19 (1), pp.63-75. ⟨10.1038/s41590-017-0012-z⟩. ⟨hal-02349815⟩
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