Mcl1 protein levels and Caspase‐7 executioner protease control axial organizer cells survival

Elena Sena (1) , Johnny Bou-Rouphael (2) , Nathalie Rocques (1) , Clémence Carron-Homo (2) , Beatrice Claude Durand (2, 1)

1 Signalisation, radiobiologie et cancer
2 LBD - Laboratoire de Biologie du Développement [IBPS]

Organizing centers are groups of specialized cells that secrete morphogens, thereby influencing development of their neighboring territories. Apoptosis is a form of programmed cell death reported to limit the size of organizers. Little is known about the identity of intracellular signals driving organizer cell death. Here we investigated in Xenopus the role of both the anti-apoptotic protein Myeloid-cell-leukemia 1 (Mcl1) and the cysteine proteases Caspase-3 and Caspase-7 in formation of the axial organizing center-the notochord-that derives from the Spemann organizer, and participates in the induction and patterning of the neuroepithelium.

Mots clés: apoptosis; mcl1; neuroepithelium; organizer; xenopus

Domaines: Embryologie et organogenèse; Morphogenèse; Organisation et fonctions cellulaires [q-bio.SC]; Interactions cellulaires [q-bio.CB]

Elena Sena, Johnny Bou-Rouphael, Nathalie Rocques, Clémence Carron-Homo, Beatrice Claude Durand. Mcl1 protein levels and Caspase‐7 executioner protease control axial organizer cells survival. Developmental Dynamics, 2020, 249 (7), pp.847-866. ⟨10.1002/dvdy.169⟩. ⟨hal-02562454⟩