The role of microtubules in secretory protein transport

Lou Fourriere (1, 2, 3) , Ana Joaquina Jimenez (1, 2, 3) , Franck Perez (1, 2, 3) , Gaelle Boncompain (1, 2, 3)

1 Institut Curie [Paris]
2 Biologie Cellulaire et Cancer
3 SU - Sorbonne Université

Microtubules are part of the dynamic cytoskeleton network and composed of tubulin dimers. They are the main tracks used in cells to organize organelle positioning and trafficking of cargos. In this review, we compile recent findings on the involvement of microtubules in anterograde protein transport. First, we highlight the importance of microtubules in organelle positioning. Then, we discuss the involvement of microtubules in different trafficking steps, in particular between the endoplasmic reticulum (ER) and the Golgi apparatus, traffic through the Golgi apparatus itself and in post-Golgi processes. A large number of studies have assessed the involvement of microtubules in the transport of cargos from the Golgi apparatus to the cell surface. We focus here on the role of kinesin motor proteins and protein interactions in post-

Domaines: Biologie cellulaire

Lou Fourriere, Ana Joaquina Jimenez, Franck Perez, Gaelle Boncompain. The role of microtubules in secretory protein transport. Journal of Cell Science, 2020, 133 (2), pp.jcs237016. ⟨10.1242/jcs.237016⟩. ⟨hal-02986327⟩