A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV

Jarrod Johnson , Nicholas de Veaux , Alexander Rives , Xavier Lahaye (1) , Sasha Lucas , Brieuc Perot , Marine Luka , Victor Garcia-Paredes , Lynn Amon , Aaron Watters , Ghaith Abdessalem , Alan Aderem , Nicolas Manel (1) , Dan Littman , Richard Bonneau , Mickaël Ménager

1 U932 - Immunité et cancer

Highlights d Network inference reveals a transcriptional map of the innate immune response to HIV d Integrating cell-specific chromatin accessibility data improves network inference d Immune responses coincide with network enrichment of IRF, STAT, and NF-kB factors d RARA and PRDM1 are validated as additional regulators of the innate response to HIV

Domaines: Sciences du Vivant [q-bio]

Jarrod Johnson, Nicholas de Veaux, Alexander Rives, Xavier Lahaye, Sasha Lucas, et al.. A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Reports, 2020, 30 (3), pp.914-931.e9. ⟨10.1016/j.celrep.2019.12.054⟩. ⟨hal-02988672⟩