A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV - Archive ouverte HAL Access content directly
Journal Articles Cell Reports Year : 2020

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV

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Jarrod Johnson
  • Function : Author
Nicholas de Veaux
  • Function : Author
Alexander Rives
  • Function : Author
Xavier Lahaye
Sasha Lucas
  • Function : Author
Brieuc Perot
  • Function : Author
Marine Luka
  • Function : Author
Victor Garcia-Paredes
  • Function : Author
Lynn Amon
  • Function : Author
Aaron Watters
  • Function : Author
Ghaith Abdessalem
  • Function : Author
Alan Aderem
  • Function : Author
Nicolas Manel
Dan Littman
  • Function : Author
Richard Bonneau
  • Function : Author
Mickaël Ménager
  • Function : Author

Abstract

Highlights d Network inference reveals a transcriptional map of the innate immune response to HIV d Integrating cell-specific chromatin accessibility data improves network inference d Immune responses coincide with network enrichment of IRF, STAT, and NF-kB factors d RARA and PRDM1 are validated as additional regulators of the innate response to HIV
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hal-02988672 , version 1 (16-11-2020)

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Jarrod Johnson, Nicholas de Veaux, Alexander Rives, Xavier Lahaye, Sasha Lucas, et al.. A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Reports, 2020, 30 (3), pp.914-931.e9. ⟨10.1016/j.celrep.2019.12.054⟩. ⟨hal-02988672⟩
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