FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence.

Charles Fouillade , Sandra Curras-Alonso , Lorena Giuranno , Eddy Quelennec , Sophie Heinrich , Sarah Bonnet-Boissinot , Arnaud Beddok , Sophie Leboucher , Hamza Umut Karakurt , Mylène Bohec , Sylvain Baulande , Marc Vooijs , Pierre Verrelle , Marie Dutreix , Arturo Londoño-Vallejo (1) , Vincent Favaudon

1 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer

One of the main limitations to anticancer radiotherapy lies in irreversible damage to healthy tissues located within the radiation field. "FLASH" irradiation at very high dose-rate is a new treatment modality that has been reported to specifically spare normal tissue from late radiation-induced toxicity in animal models and therefore could be a promising strategy to reduce treatment toxicity.

Domaines: Organisation et fonctions cellulaires [q-bio.SC]

Charles Fouillade, Sandra Curras-Alonso, Lorena Giuranno, Eddy Quelennec, Sophie Heinrich, et al.. FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence.. Clinical Cancer Research, 2020, 26 (6), pp.1497-1506. ⟨10.1158/1078-0432.CCR-19-1440⟩. ⟨hal-03023267⟩