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Journal Articles Annales d'Endocrinologie Year : 2000

Vascular endothelial growth factors and angiogenesis.

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Abstract

VEGF was discovered in 1989. Research -conducted over the past 10 years has -demonstrated that VEGF is a major regulator of angiogenesis and vasculogenesis. This paper reviews the molecular data on the multiple forms of VEGF, their signalling and accessory receptors. Five genes encoding VEGF-like proteins have been identified; the different isoforms of each VEGF molecule are generated by alternative splicing mechanisms. The different VEGF's recognize signalling tyrosine kinase receptors (Flt-1, Flk-1 and Flt-4) and accessory receptors. VEGF expression is stimulated by hypoxia-dependent and -independent mechanisms. Hypoxic responses are mediated by specific transcription factors that are expressed in a tissue dependent fashion and that are developmentally regulated. VEGF is thought to play a role in tumor angiogenesis and may contribute to cardioprotection in ischemic heart -diseases. Its role in pulmonary hypertension induced by chronic hypoxia is discussed. This review also stresses the difficulty of applying results from in vitro -studies to in vivo situations.
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Dates and versions

hal-03034034 , version 1 (01-12-2020)

Identifiers

  • HAL Id : hal-03034034 , version 1
  • PUBMED : 10790595

Cite

C. Frelin, A. Ladoux, Gisela d'Angelo. Vascular endothelial growth factors and angiogenesis.. Annales d'Endocrinologie, 2000, 61 (1), pp.70-4. ⟨hal-03034034⟩
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