Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) and their oxidation-sensitive polymersomes

Yangwei Deng (1) , Hui Chen (1) , Xinfeng Tao (2, 1) , Sylvain Trépout (3) , Jun Ling (4) , Min-Hui Li (1, 2)

1 IRCP - Institut de Recherche de Chimie Paris
2 Beijing University of Chemical Technology
3 Institut Curie [Paris]
4 Zhejiang University

Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) (PEGb-PMeSPG) were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine Nthiocarboxyanhydride (MeSPG-NTA) initiated by amino-terminated PEG. The self-assemblies of three PEG-b-PMeSPG copolymers with different PMeSPG block lengths were first prepared by nanoprecipitation method using THF and DMF, respectively, as the organic solvent, and their morphologies were studied by Cryo-EM and DLS. To prepare polymersomes loaded with glucose oxidase (GOx), double emulsion method followed by extrusion treatment was employed. The oxidation-responsive disruption of polymersomes was achieved upon the introduction of glucose because of the oxidants generated insitu by GOx/glucose.

Mots clés: Polypeptoid; Self-assembly; Polymersome; Oxidation-responsive; Glucose oxidase

Domaines: Polymères

Yangwei Deng, Hui Chen, Xinfeng Tao, Sylvain Trépout, Jun Ling, et al.. Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) and their oxidation-sensitive polymersomes. Chinese Chemical Letters, 2020, 31 (7), pp.1931-1935. ⟨10.1016/j.cclet.2019.12.026⟩. ⟨hal-03051796⟩