Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids

Xinfeng Tao (1) , Hui Chen (2, 3) , Sylvain Trépout (4) , Jiayu Cen (5) , Jun Ling (5, 6) , Min-Hui Li (2, 7)

1 East China University of Science and Technology
2 IRCP - Institut de Recherche de Chimie Paris
3 Beijing Forestry University
4 Institut Curie [Paris]
5 Zhejiang University
6 Department of Microbiology, College of Life Sciences
7 Beijing University of Chemical Technology

Biocompatible polymersomes are prepared from amphiphilic block copolypeptoids with aggregation-induced emission, where the hydrophobic block P(TPE-NAG) is a tetraphenylethylene (TPE)-modified poly(N-allylglycine) and the hydrophilic block is polysarcosine. These nanoparticles are non-cytotoxic and show strong fluorescence emission in aqueous solution. PNAG-b-PSar was synthesized using benzylamine-initiated ROP of N-allylglycine NTA (NAG-NTA) and sarcosine NTA (Sar-NTA). To

Domaines: Polymères

Xinfeng Tao, Hui Chen, Sylvain Trépout, Jiayu Cen, Jun Ling, et al.. Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids. Chemical Communications, 2019, 55 (90), pp.13530-13533. ⟨10.1039/C9CC07501A⟩. ⟨hal-03051819⟩