KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling - Institut Curie Accéder directement au contenu
Article Dans Une Revue Journal of Cell Biology Année : 2021

KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling

Résumé

The regulated trafficking of AMPA-type glutamate receptors (AMPARs) from dendritic compartments to the synaptic membrane in response to neuronal activity is a core mechanism for long-term potentiation (LTP). However, the contribution of the microtubule cytoskeleton to this synaptic transport is still unknown. In this work, using electrophysiological, biochemical, and imaging techniques, we have found that one member of the kinesin-3 family of motor proteins, KIF13A, is specifically required for the delivery of AMPARs to the spine surface during LTP induction. Accordingly, KIF13A depletion from hippocampal slices abolishes LTP expression. We also identify the vesicular protein centaurin-α1 as part of a motor transport machinery that is engaged with KIF13A and AMPARs upon LTP induction. Finally, we determine that KIF13A is responsible for the remodeling of Rab11-FIP2 endosomal structures in the dendritic shaft during LTP. Overall, these results identify specific kinesin molecular motors and endosomal transport machinery that catalyzes the dendrite-to-synapse translocation of AMPA receptors during synaptic plasticity.
Fichier principal
Vignette du fichier
KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling.pdf (16.83 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03406219 , version 1 (27-10-2021)

Identifiants

Citer

Yolanda Gutiérrez, Sergio López-García, Argentina Lario, Silvia Gutiérrez-Eisman, Cédric Delevoye, et al.. KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling. Journal of Cell Biology, 2021, 220 (6), pp.e202003183. ⟨10.1083/jcb.202003183⟩. ⟨hal-03406219⟩
27 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More