Tissue-specific targeting of DNA nanodevices in a multicellular living organism - Archive ouverte HAL Access content directly
Journal Articles eLife Year : 2021

Tissue-specific targeting of DNA nanodevices in a multicellular living organism

Tissue-specific targeting of DNA nanodevices in a multicellular living organism.

, , (1) , , , (2) , (3) , , , (4)
1
2
3
4
Kasturi Chakraborty
Palapuravan Anees
Sunaina Surana
Simona Martin
  • Function : Author
Jihad Aburas
  • Function : Author
Sandrine Moutel
Franck Perez
Sandhya Koushika
Paschalis Kratsios

Abstract

Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing the full potential of DNA nanodevices also requires ways to target them to specific cell types in vivo. Here, we show that by exploiting either endogenous or synthetic receptor-ligand interactions and leveraging the biological barriers presented by the organism, we can target extraneously introduced DNA nanodevices to specific cell types in Caenorhabditis elegans , with subcellular precision. The amenability of DNA nanostructures to tissue-specific targeting in vivo significantly expands their utility in biomedical applications and discovery biology.

Dates and versions

hal-03416917 , version 1 (05-11-2021)

Identifiers

Cite

Kasturi Chakraborty, Palapuravan Anees, Sunaina Surana, Simona Martin, Jihad Aburas, et al.. Tissue-specific targeting of DNA nanodevices in a multicellular living organism. eLife, 2021, 10, ⟨10.7554/eLife.67830⟩. ⟨hal-03416917⟩
9 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More