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Journal Articles Bulletin du Cancer Year : 2020

Stratégie diagnostique des sarcomes des tissus mous de l’enfant et adolescent

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Abstract

Soft tissue sarcomas in children are rare tumor, representing around 6 to 7% of children cancer. They spread mostly sporadically (90%) and therefore are rarely associated to an underlying constitutional genetic disease (10%). About half of those sarcomas are rhabdomyosarcomas and the others are a very heterogenous histologic group with various bio-pathologies and prognosis. Clinical presentation is mainly a soft tissue lump often difficult to distinguish from more frequent benign causes (malformative, infectious, benign, or pseudotumor). Inappropriate initial diagnosis work-up has a strong impact on soft tissue sarcomas' prognosis. Adapted complementary investigations (first ultrasound and MRI) are important to compile arguments for a malign origin and to indicate a biopsy. However, predictive value of imaging exams still remains imperfect, and histological analysis by percutaneous image-guided biopsy and sometimes by surgical biopsy is often necessary. Authors realize an update on optimal diagnostic pathway including molecular tests in presence of a soft tissue mass in a child.
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hal-03494073 , version 1 (17-10-2022)

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Attribution - NonCommercial - CC BY 4.0

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Charlotte Collignon, Hervé J. Brisse, Lauriane Lemelle, Liesbeth Cardoen, Arnaud Gauthier, et al.. Stratégie diagnostique des sarcomes des tissus mous de l’enfant et adolescent. Bulletin du Cancer, 2020, 107, pp.963 - 971. ⟨10.1016/j.bulcan.2020.06.008⟩. ⟨hal-03494073⟩
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