[Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].

C. Simon (1) , Christophe Morin , B Bruguerolle , J. Tillement (2)

1 IETR - Institut d'Electronique et de Télécommunications de Rennes
2 INSERM - Institut National de la Santé et de la Recherche Médicale

A mitochondrial dysfunction has been suggested to explain chronic renal toxicity observed in ciclosporine A therapy. Our study has investigated whether trimetazidine allows inhibition of mitochondrial alteration induced by ciclosporine A. Oxidative phosphorylation was measured by polarography, calcium fluxes by a specific calcium electrode and the mitochondrial swelling by determination of the optical density at 520 nm, using a spectrophotometer. The ciclosporine A effect on the respiratory control was fully inhibited by trimetazidine (EC50 5.10 x 10(-7) M; Emax 11 per cent). Trimetazidine also inhibited the ciclosporine effects on calcium fluxes, i.e. calcium accumulation into the matrix and delay of efflux. Trimetazidine allows a decrease of mitochondrial dysfunction induced by ciclosporine A.

Domaines: Biochimie [q-bio.BM]; Neurobiologie; Biologie structurale [q-bio.BM]; Organisation et fonctions cellulaires [q-bio.SC]; Interactions cellulaires [q-bio.CB]; Pharmacologie; Médicaments

C. Simon, Christophe Morin, B Bruguerolle, J. Tillement. [Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].. Thérapie, 1970, 56 (5), pp.583-7. ⟨hal-02268288⟩