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Article dans une revue

Consecutive Food and Respiratory Allergies Amplify Systemic and Gut but Not Lung Outcomes in Mice

Abstract : Epidemiological data suggest a link between food allergies and the subsequent development of asthma. Although this progression may result from the additional effects of exposure to multiple allergens, whether both allergies amplify each other's effects remains unknown. This study investigated whether oral exposure to food allergens influences the outcomes of subsequent respiratory exposure to an asthma-inducing allergen. Mice were sensitized and orally challenged with wheat (FA) and then exposed to house dust mite (HDM) extract (RA). Immunoglobulin (Ig), histamine, and cytokine levels were assayed by ELISA. Intestinal and lung physiology was assessed. Ig levels, histamine release, and cytokine secretion were higher after exposure to both allergens than after separate exposure to each. Intestinal permeability was higher, although airway hyper-responsiveness and lung inflammation remained unchanged. Exposure to food and respiratory allergens amplifies systemic and gut allergy-related immune responses without any additional effect on lung function and inflammation.
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Soumis le : lundi 23 juillet 2018 - 16:58:24
Dernière modification le : jeudi 20 janvier 2022 - 13:24:02




Gregory Bouchaud, Paxcal Gourbeyre, Tiphaine Bihouée, Phillippe Aubert, David Lair, et al.. Consecutive Food and Respiratory Allergies Amplify Systemic and Gut but Not Lung Outcomes in Mice. Journal of Agricultural and Food Chemistry, American Chemical Society, 2015, Equipe 6, 63 (28), pp.6475--6483. ⟨10.1021/acs.jafc.5b02338⟩. ⟨hal-01830976⟩



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