1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2004

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

C. Kunick
  • Fonction : Auteur
K. Lauenroth
  • Fonction : Auteur
T. Lemcke
  • Fonction : Auteur

Résumé

Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3beta selectivity of 1-azakenpaullone compared to other paullone derivatives.
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Dates et versions

hal-00020128 , version 1 (06-03-2006)

Identifiants

  • HAL Id : hal-00020128 , version 1

Citer

C. Kunick, K. Lauenroth, M. Leost, L. Meijer, T. Lemcke. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorganic and Medicinal Chemistry Letters, 2004, 11, pp.413-416. ⟨hal-00020128⟩
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