OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats.

I. Callebaut (1) , J.P. Mornon (1)

1 IMPMC - Institut de minéralogie et de physique des milieux condensés

In this study, we describe a novel domain, OCRE, which is shared by the recently identified angiogenic factor VG5Q and a specific family of RNA-binding motif proteins. The OCRE domain is characterized by a 5-fold, imperfectly repeated octameric sequence, which includes a triplet of often-conserved aromatic amino acids predicted to form a beta-strand and in which the slightly modified fifth repeat might act as a repeat terminator. Although the function of this domain remains to be elucidated, the domain architecture of OCRE containing proteins and experimental data suggest a role in RNA metabolism and/or in signalling pathways activated by the tumor necrosis factor superfamily of cytokines.

Mots clés: PUTATIVE TUMOR-SUPPRESSOR; RNA-BINDING PROTEIN; IDENTIFICATION; 3P21.3; CELLS; PATTERNS; DATABASE; REGION; GENES; MOTIF

I. Callebaut, J.P. Mornon. OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats.. Bioinformatics, 2005, 21, pp.699-702. ⟨hal-00021608⟩