Reconsolidation after remembering an odor-reward association requires NMDA receptors. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Learning and Memory Année : 2005

Reconsolidation after remembering an odor-reward association requires NMDA receptors.

Résumé

A rapidly learned odor discrimination task based on spontaneous foraging behavior of the rat was used to evaluate the role of N-methyl-D-aspartate (NMDA) receptors (NMDARs) in ongoing memory consolidation. Rats were trained in a single session to discriminate among three odors, one of which was associated with palatable food reward. Previous experiments showed that the NMDAR antagonist DL-APV induced amnesia for this task when injected immediately after training. In the present study, memory was reactivated 24 h after training by exposure to the rewarded odor within the experimental context after which rats received an intracerebroventricular injection of APV. Combined reactivation-drug treatment induced profound amnesia when tested 48 h later. Animals receiving drug alone, in absence of reactivation, showed perfect retention. It is concluded that NMDARs support a consolidation process taking place after memory reactivation.

Dates et versions

hal-00087264 , version 1 (21-07-2006)

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M. Torras-Garcia, J. Lelong, S. Tronel, S.J. Sara. Reconsolidation after remembering an odor-reward association requires NMDA receptors.. Learning and Memory, 2005, 12, pp.18-22. ⟨10.1101/lm.80905⟩. ⟨hal-00087264⟩
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