Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Parasitology Research Année : 2006

Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax.

Résumé

Blood stages of Plasmodium vivax induce the development of caveolae and caveola–vesicle complexes (CVC) in the membrane of their host erythrocyte. Caveolae are found in almost all types of cells and are involved in endogenous processes as calcium and cholesterol homeostasis, cell signalling, transporting, ligand internalization and transcytosis of serum components. Major structural components of caveolae are the proteins caveolins and flotillins. The functional role of caveolae in the P. vivax-infected erythrocyte is not properly understood. As these organelles have been shown to contain malaria antigens, it has been suggested that they are involved in the transport and release of specific parasite antigens from the infected erythrocyte and in the uptake of plasma proteins. Using specific antibodies to classical caveolae proteins and an immunolocalization approach, we found caveolin-2, caveolin-3, and flotillin-2 in the vesicle profiles and some CVC of P. vivax-infected erythrocytes. Caveolin-1–3 were not found in uninfected erythrocytes. This is the first report of identification and localization of caveolins in the CVC present in erythrocytes infected with P. vivax, thereby providing evidence of the role of this particular organelle in the protein-trafficking pathway that connect parasite-encoded proteins with the erythrocyte cytoplasm and the cell surface throughout the asexual blood cycle of vivax malaria parasite.

Dates et versions

hal-00089649 , version 1 (21-08-2006)

Identifiants

Citer

Carmen Bracho, Irene Dunia, Mirtha Romano, Graça Raposo, Mercedes de La Rosa, et al.. Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax.. Parasitology Research, 2006, 99(2), pp.153-159. ⟨10.1007/s00436-006-0139-6⟩. ⟨hal-00089649⟩
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