[Pharmacological treatment of neurogenic detrusor hyperactivity: intrathecal drugs]

P. Denys , a Even Schneider (1) , O. Remy-Neris (2, 3) , D. Ben-Smail , E. Chartier-Kastler (4) , A. Ruffion , B. Bussel (5, 6)

1 Department of Biology/Cell and Developmental Biology
2 LaTIM - Laboratoire de Traitement de l'Information Medicale
3 Service de médecine physique et de réadaptation
4 CHU Pitié-Salpêtrière [AP-HP]
5 Physiologie et physiopathologie de la motricité chez l'homme
6 Department of Neurological Rehabilitation

Intrathecal clonidine has been tested in spinal cord injury patients not supporting or resistant to anticholinergic drugs. Although the acute effect of clonidine on urodynamic parameters was satisfactory, cardiovascular adverse effects limited the long-term efficacy of this treatment. Intrathecal baclofen has a limited effect on overactive bladder in patients with spinal spasticity, but can modify the quality of erections and induce an incapacity to trigger ejaculation by vibratory penile stimulation.

Domaines: Médecine vétérinaire et santé animale

P. Denys, a Even Schneider, O. Remy-Neris, D. Ben-Smail, E. Chartier-Kastler, et al.. [Pharmacological treatment of neurogenic detrusor hyperactivity: intrathecal drugs]. Progrès en Urologie, 2007, 17 (3), pp.564-7. ⟨hal-00272345⟩