Addition of a Chiral Copper Reagent Derived from Propargylic Oxazolidininone to Aldehydes

Nacira Alouane (1) , Frederic Bernaud (1) , Jerôme Marrot (2) , Emmanuel Vrancken (1) , Pierre Mangeney (1)

1 CO - Chimie Organique
2 SIRCOB - Synthèse, interactions et réactivité en chimie organique et bioorganique

The copper reagent arising from an optically pure propargylic oxazolidinone was found to react regio- and diastereoselectively with aldehydes, leading, in a one-pot procedure, to the anti homopropargylic amino alcohols derivatives in good yields.

Domaines: Chimie organique

Nacira Alouane, Frederic Bernaud, Jerôme Marrot, Emmanuel Vrancken, Pierre Mangeney. Addition of a Chiral Copper Reagent Derived from Propargylic Oxazolidininone to Aldehydes. Organic Letters, 2005, 7 (26), pp.5797-5800. ⟨10.1021/ol0522743⟩. ⟨hal-00382888⟩