A Practical Diastereoselective Synthesis of syn-alpha-hydroxyaminonitriles

Fatoumia Abdillah (1) , Loïc Almeras (1) , Eric Leclerc (1) , Pierre Mangeney (1) , Emmanuel Vrancken (1)

1 CO - Chimie Organique

An efficient and practical one pot two-step synthesis of syn-alpha-hydroxyaminonitriles through an acylation-diastereoselective reduction sequence from lithiated alpha-aminonitrile is achieved.

Mots clés: amino alcohols; reduction; diastereoselectivity; acyl cyanide; dynamic kinetic resolution

Domaines: Chimie organique

Fatoumia Abdillah, Loïc Almeras, Eric Leclerc, Pierre Mangeney, Emmanuel Vrancken. A Practical Diastereoselective Synthesis of syn-alpha-hydroxyaminonitriles. SYNLETT, 2005, 2005 (6), pp.1033-1035. ⟨10.1055/s-2005-864838⟩. ⟨hal-00382906⟩