Acute ileal inflammatory cytokine response induced by irradiation is modulated by subdiaphragmatic vagotomy. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Journal of Neuroimmunology Année : 2005

Acute ileal inflammatory cytokine response induced by irradiation is modulated by subdiaphragmatic vagotomy.

Résumé

Neural involvement plays a role in the genesis of the peripheral inflammatory process that contributes to the irradiation intestinal disorders. However, little is known about the role of vagus nerve in modulating inflammatory process in rat. Here, we have shown that the NF-kappaB activation was consistent with the acute overexpression of pro-inflammatory cytokines (IL- 1beta, TNF-alpha, IL-6) at 3, 6, and 12 h induced by whole-body irradiation (8 Gy). Subdiaphragmatic vagotomy reduced NF-kappaB activation and cytokine transcription in the early period post-irradiation. In contrast, vagotomy amplified overexpression of irradiation-induced anti-cytokines (IL-10, IL-1Ra) and of receptors involved in anti-inflammatory effects (IL- 1RII, TNFRII). These results show that the vagus nerve is a pro-inflammatory pathway in early irradiation-induced intestinal inflammation.

Dates et versions

hal-00405241 , version 1 (20-07-2009)

Identifiants

Citer

Christine Linard, C. M. Marquette, Didier Clarençon, Monique Galonnier, Jacques Mathieu, et al.. Acute ileal inflammatory cytokine response induced by irradiation is modulated by subdiaphragmatic vagotomy.. Journal of Neuroimmunology, 2005, 168 (1-2), pp.83-95. ⟨10.1016/j.jneuroim.2005.07.007⟩. ⟨hal-00405241⟩
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