Successful anti-TNFalpha treatment in a child with posttransplant recurrent focal segmental glomerulosclerosis. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue American Journal of Transplantation Année : 2009

Successful anti-TNFalpha treatment in a child with posttransplant recurrent focal segmental glomerulosclerosis.

D. Bruckner
  • Fonction : Auteur
V. Emal-Aglae
  • Fonction : Auteur
G. Deschênes
  • Fonction : Auteur
A. Bensman
  • Fonction : Auteur
T. Ulinski
  • Fonction : Auteur

Résumé

Posttransplant recurrence of focal and segmental glomulosclerosis (FSGS) occurs in approximately 30% of patients, and remains after uncontrolled despite increased immunosuppression and plasma exchanges (PE) in approximately 30% of cases. New immunosuppressive drugs might then be warranted. We report the case of a 15-year-old boy with FSGS leading to end-stage renal disease (ESRD) who presented with an early posttransplant recurrence of disease. Reinforced immunosuppression and PE resulted in partial and transient disease control, but proteinuria significantly decreased with anti-TNFalpha treatment (infliximab then etanercep). This is the first case report of successful anti-TNFalpha treatment despite a constant high activity of FSGS, as demonstrated by relapse after discontinuation of anti-TNFalpha agents.

Domaines

Immunologie

Dates et versions

hal-00453333 , version 1 (04-02-2010)

Identifiants

Citer

Sylvie Leroy, Vincent Guigonis, D. Bruckner, V. Emal-Aglae, G. Deschênes, et al.. Successful anti-TNFalpha treatment in a child with posttransplant recurrent focal segmental glomerulosclerosis.. American Journal of Transplantation, 2009, 9 (4), pp.858-61. ⟨10.1111/j.1600-6143.2009.02550.x⟩. ⟨hal-00453333⟩
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