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Article Dans Une Revue European Psychiatry Année : 2008

Two-year study of relapse prevention by a new education program in schizophrenic patients treated with the same antipsychotic drug.

Jean-Paul Chabannes
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Nadine Bazin
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Denis Leguay
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Philippe Nuss
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Ricardo P Garay
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Maurice Ferreri
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Résumé

It is not clear whether patient's psycho-education enhances compliance to antipsychotic treatments and reduces the number of relapses. Here we investigated the impact of a new psycho-educational program (SOLEDUC) on the one- and two-years rate of relapse (primary outcome measure) and a number of clinical assessments (secondary outcome measures). This was a multicentric French clinical trial (51 centers) of Phase IV, open, controlled, randomized, consisting in two parallel groups: the Soleduc group (N=111) and the control group (N=109). All subjects received a variable dose over the 2-year period of the same antipsychotic drug (amisulpride). Soleduc consisted of a 7-session program (1h per session), presented three times (at baseline, 6-months and 12-months). Patients in the control group received a non-specific psychosocial training for an equivalent period of time. The models of Andersen-Gill (AG) and Prentice, Williams and Peterson (PWP) were used to analyze relapses. Patients in the Soleduc group attended 14.8+/-6.1 sessions (mean+/-SD), including 17 patients who never attended a session. Intent to treat analysis showed less patients relapsing in the Soleduc group as compared to the control group (21.6% versus 28.4% after 1 year and 84.4% versus 90.8% after 2years), but the differences were not statistically significant. Relapse risk was significantly reduced for patients who followed at least 7 modules (p=0.015 AG-test; p<0.001 PWP-test). In conclusion, no significant differences in relapse rates were found between patients attending the Soleduc program and the control group. Attendance of at least 7 out of 21 program sessions was required to see a modest, but significant two-year relapse prevention in schizophrenia. Other well designed studies are required to evaluate the medical impact of patient's education programs.

Domaines

Chimie organique

Dates et versions

hal-00650142 , version 1 (09-12-2011)

Identifiants

Citer

Jean-Paul Chabannes, Nadine Bazin, Denis Leguay, Philippe Nuss, Charles-Siegfried Peretti, et al.. Two-year study of relapse prevention by a new education program in schizophrenic patients treated with the same antipsychotic drug.. European Psychiatry, 2008, 23 ((1)), pp.8-13. ⟨10.1016/j.eurpsy.2007.09.003⟩. ⟨hal-00650142⟩
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