Iron and ROS control of the DownSTream mRNA decay pathway is essential for plant fitness. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue EMBO Journal Année : 2012

Iron and ROS control of the DownSTream mRNA decay pathway is essential for plant fitness.

Résumé

A new regulatory pathway involved in plant response to oxidative stress was revealed using the iron-induced Arabidopsis ferritin AtFER1 as a model. Using pharmacological and genetic approaches, the DownSTream (DST) cis-acting element in the 3'-untranslated region of the AtFER1 mRNA was shown to be involved in the degradation of this transcript, and oxidative stress triggers this destabilization. In the two previously identified trans-acting mutants (dst1 and dst2), AtFER1 mRNA stability is indeed impaired. Other iron-regulated genes containing putative DST sequences also displayed altered expression. Further physiological characterization identified this oxidative stress-induced DST-dependent degradation pathway as an essential regulatory mechanism to modulate mRNA accumulation patterns. Alteration of this control dramatically impacts plant oxidative physiology and growth. In conclusion, the DST-dependent mRNA stability control appears to be an essential mechanism that allows plants to cope with adverse environmental conditions.

Dates et versions

hal-00777600 , version 1 (17-01-2013)

Identifiants

Citer

Karl Ravet, Guilhem Reyt, Nicolas Arnaud, Gabriel Krouk, El-Batoul Djouani, et al.. Iron and ROS control of the DownSTream mRNA decay pathway is essential for plant fitness.. EMBO Journal, 2012, 31 (1), pp.175-86. ⟨10.1038/emboj.2011.341⟩. ⟨hal-00777600⟩
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