Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2004

Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids.

Résumé

The amino-zinc-ene-enolate cyclization reaction is a straightforward route to the synthesis of 3-substituted prolines. Herein we report the application of this reaction to the syntheses of proline chimeras of lysine, glutamic acid, glutamine, arginine, and serine. All these compounds were obtained in enantiomerically pure form and suitably protected for peptide synthesis.

Domaines

Chimie organique

Dates et versions

hal-00812414 , version 1 (12-04-2013)

Identifiants

Citer

Jean Quancard, Aurélie Labonne, Yves Jacquot, Gérard Chassaing, Solange Lavielle, et al.. Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids.. Journal of Organic Chemistry, 2004, 69 ((23)), pp.7940-8. ⟨10.1021/jo048762q⟩. ⟨hal-00812414⟩
106 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More