Absorption of zidovudine in patients with diarrhoea.

G. Zorza , L. Beaugerie (1) , A. M. Taburet , Y. Le Quintrec , E. Singlas

1 UPMC - Université Pierre et Marie Curie - Paris 6

Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea.

Domaines: Chimie organique

G. Zorza, L. Beaugerie, A. M. Taburet, Y. Le Quintrec, E. Singlas. Absorption of zidovudine in patients with diarrhoea.. European Journal of Clinical Pharmacology, 1993, 44 ((5)), pp.501-3. ⟨hal-00815135⟩