Iron Oxide Monocrystalline Nanoflowers for Highly Efficient Magnetic Hyperthermia

P. Hugounenq (1) , M. Levy (2) , D. Alloyeau (3) , L. Lartigue (2) , Emeric Dubois (1) , V. Cabuil (1) , C. Ricolleau (3) , S. Roux (4) , C. Wilhelm (2) , F. Gazeau (2) , R. Bazzi (4, 1)

1 PECSA - Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques
2 MSC - Matière et Systèmes Complexes
3 MPQ (UMR_7162) - Laboratoire Matériaux et Phénomènes Quantiques
4 UTINAM - Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213)

Magnetic nanoparticles exhibit a high potential to selectively treat cancer by hyperthermia provided that high heating capacity can be reached. In this work, we report an efficient synthesis of novel structures of magnetic iron oxide. The particles, obtained by applying a modified “polyol” protocol, present a particular shape: they look constituted of smaller grains of approximately 11 nm, assembled in a flower-shaped structure. These nanoflowers, dispersed in water at physiological pH, present particularly interesting magnetic properties and a great capacity of heating. The value of the specific loss power (SLP) of these nanoflowers is 1 order of magnitude higher than the SLP reported for conventional 11 nm single-domain maghemite nanoparticles in the same condition of field exposure.

Mots clés: Nanoparticles; Metal oxide nanoparticles; Magnetic properties; Transmission electron microscopy; Hyperthermia

Domaines: Chimie

P. Hugounenq, M. Levy, D. Alloyeau, L. Lartigue, Emeric Dubois, et al.. Iron Oxide Monocrystalline Nanoflowers for Highly Efficient Magnetic Hyperthermia. Journal of Physical Chemistry C, 2012, 116 (29), pp.15702-15712. ⟨10.1021/jp3025478⟩. ⟨hal-00820701⟩