[Osteoarticular infections: clinical studies].

E. Grimprel (1) , M. Lorrot (2) , H. Haas , D. Pinquier , N. Parez (3) , A. Ferroni , R. Cohen (4, 5)

1 CHU Trousseau [APHP]
2 Département de Pédiatrie
3 UPMC - Université Pierre et Marie Curie - Paris 6
4 Association Clinique et Thérapeutique du Val-de-Marne (ACTIV)
5 Service de microbiologie

Management of paediatric skeletal infections remains delicate in France due to the absence of general agreement or official recommendations from the French National Societies. However, practices have evolved since 40 years towards simplified and mostly ambulatory treatment modalities. The Paediatric Infectious Diseases Group of the French Society of Paediatrics (GPIP) has elaborated guidelines funded on the joint analysis of bacterial epidemiology, comparison of common antimicrobial spectra, pharmacokinetic and pharmacodynamic parameters and clinical studies. The aim of this article is to review the evolution of therapeutic concepts of treatment of bone and joint infections in paediatrics for 40 years with the aid of main published clinical studies.

Domaines: Chimie organique

E. Grimprel, M. Lorrot, H. Haas, D. Pinquier, N. Parez, et al.. [Osteoarticular infections: clinical studies].. Archives de Pédiatrie, 2008, 15 Suppl 2, pp.S68-73. ⟨10.1016/S0929-693X(08)74219-2⟩. ⟨hal-00944423⟩