Homotypic and Heterotypic Adhesion Induced by Odorant Receptors and the β2-Adrenergic Receptor. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2013

Homotypic and Heterotypic Adhesion Induced by Odorant Receptors and the β2-Adrenergic Receptor.

Résumé

In the mouse olfactory system regulated expression of a large family of G Protein-Coupled Receptors (GPCRs), the Odorant Receptors (ORs), provides each sensory neuron with a single OR identity. In the wiring of the olfactory sensory neuron projections, a complex axon sorting process ensures the segregation of >1,000 subpopulations of axons of the same OR identity into homogeneously innervated glomeruli. ORs are critical determinants in axon sorting, and their presence on olfactory axons raises the intriguing possibility that they may participate in axonal wiring through direct or indirect trans-interactions mediating adhesion or repulsion between axons. In the present work, we used a biophysical assay to test the capacity of ORs to induce adhesion of cell doublets overexpressing these receptors. We also tested the β2 Adrenergic Receptor, a non-OR GPCR known to recapitulate the functions of ORs in olfactory axon sorting. We report here the first evidence for homo- and heterotypic adhesion between cells overexpressing the ORs MOR256-17 or M71, supporting the hypothesis that ORs may contribute to olfactory axon sorting by mediating differential adhesion between axons.

Dates et versions

hal-00946198 , version 1 (13-02-2014)

Identifiants

Citer

Marion Richard, Sophie Jamet, Coralie Fouquet, Caroline Dubacq, Nicole Boggetto, et al.. Homotypic and Heterotypic Adhesion Induced by Odorant Receptors and the β2-Adrenergic Receptor.. PLoS ONE, 2013, 8 (12), pp.e80100. ⟨10.1371/journal.pone.0080100⟩. ⟨hal-00946198⟩
183 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More