β,γ-Diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group.

Andrii Stanovych (1) , Régis Guillot (2) , Cyrille Kouklovsky , Emeric Miclet (3, 4) , Valérie Alezra

1 IMMM - Institut des Molécules et Matériaux du Mans
2 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay
3 UPMC - Université Pierre et Marie Curie - Paris 6
4 SSFMB - Synthèse, Structure et Fonction de Molécules Bioactives

: Using a β,γ-diamino acid, several small hybrid α/γ peptides have been synthesized and their conformations investigated through extensive NMR studies and molecular dynamics. A tripeptide and a tetrapeptide have thus shown several hydrogen bonds in solution, including a 13-membered ring involving the β-nitrogen.

Domaines: Chimie organique

Andrii Stanovych, Régis Guillot, Cyrille Kouklovsky, Emeric Miclet, Valérie Alezra. β,γ-Diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group.. Amino Acids, 2014, 46 (12), pp.2753-2757. ⟨10.1007/s00726-014-1831-y⟩. ⟨hal-01064605⟩