Polymodal activation of the endocannabinoid system in the extended amygdala. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Nature Neuroscience Année : 2011

Polymodal activation of the endocannabinoid system in the extended amygdala.

Résumé

The reason why neurons synthesize more than one endocannabinoid (eCB) and how this is involved in the regulation of synaptic plasticity in a single neuron is not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate different forms of plasticity in the extended amygdala of rats. Dendritic L-type Ca(2+) channels and the subsequent release of 2-AG acting on presynaptic CB1 receptors triggered retrograde short-term depression. Long-term depression was mediated by postsynaptic mGluR5-dependent release of anandamide acting on postsynaptic TRPV1 receptors. In contrast, 2-AG/CB1R-mediated retrograde signaling mediated both forms of plasticity in the striatum. These data illustrate how the eCB system can function as a polymodal signal integrator to allow the diversification of synaptic plasticity in a single neuron.
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Dates et versions

hal-01160051 , version 1 (04-06-2015)

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Nagore Puente, Yihui Cui, Olivier Lassalle, Mathieu Lafourcade, François Georges, et al.. Polymodal activation of the endocannabinoid system in the extended amygdala.. Nature Neuroscience, 2011, 14 (12), pp.1542-7. ⟨10.1038/nn.2974⟩. ⟨hal-01160051⟩
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