Richness of human gut microbiome correlates with metabolic markers - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Nature Année : 2013

Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier
Edi Prifti
Mathieu Almeida
  • Fonction : Auteur
Jean-Michel Batto
  • Fonction : Auteur
Sean Kennedy
  • Fonction : Auteur
  • PersonId : 1203215
Pierre Léonard
  • Fonction : Auteur
Florence Levenez
  • Fonction : Auteur
Nicolas Pons
  • Fonction : Auteur
Shinichi Sunagawa
  • Fonction : Auteur
Julien Tap
Karsten Kristiansen
Peer Bork
  • Fonction : Auteur
Stanislav Ehrlich
  • Fonction : Auteur
Florence Haimet
  • Fonction : Auteur

Résumé

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Fichier principal
Vignette du fichier
2013LeChatelier.pdf (281.47 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01190602 , version 1 (18-03-2024)

Identifiants

Citer

Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, et al.. Richness of human gut microbiome correlates with metabolic markers. Nature, 2013, 500 (7464), pp.541-546. ⟨10.1038/nature12506⟩. ⟨hal-01190602⟩
12260 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More