Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models

S. Miquel (1, 2, 3) , R. Martín (2) , A. Lashermes (4, 1) , Marion Gillet (5) , M. Meleine (4, 1) , A. Gelot (4, 1) , A. Eschalier (6, 7, 4, 1) , D. Ardid (6, 4, 1) , L. G. Bermúdez-Humarán (2) , H. Sokol (8, 2, 8, 9) , M. Thomas (2) , Vassilia Theodorou (10, 5) , P. Langella (2) , F. A. Carvalho (4, 11, 1)

1 UdA - Université d'Auvergne - Clermont-Ferrand I
2 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
3 LMGE - Laboratoire Microorganismes : Génome et Environnement
4 Neuro-Dol - Neuro-Dol
5 ToxAlim - ToxAlim
6 Pharmacologie fondamentale et clinique de la douleur
7 Service de Pharmacologie
8 CHU Saint-Antoine [AP-HP]
9 UPMC - Université Pierre et Marie Curie - Paris 6
10 UTA - Toxicologie Alimentaire
11 INPA - Instituto Nacional de Pesquisas da Amazônia = National Institute of Amazonian Research

Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

Domaines: Hépatologie et Gastroentérologie

S. Miquel, R. Martín, A. Lashermes, Marion Gillet, M. Meleine, et al.. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models. Scientific Reports, 2015, 6, pp.19399. ⟨10.1038/srep19399⟩. ⟨hal-01263911⟩