Influence of a neoglycolipid and its PEO-lipid moiety on the organization of phospholipid monolayers

P Dynarowicz-Latka , V Rosilio , P Boullanger , P Fontaine , M Goldmann (1) , A Baszkin

1 INSP - Institut des Nanosciences de Paris

The surface properties of the neoglycolipid (GlcNAcE(3)G(28)) and of its PEO-lipid (E(3)G(28)) moiety mixed with phospholipids (dipalmitoylphosphatidylcholine, DPPC; distearoylphosphatidylcholine, DSPC; diarachidoylphosphatidylcholine, DAPC; and dibehenoylphosphatidylcholine, DBPC) were studied in Langmuir monolayers at various mixture compositions and surface pressures. The pi-A isotherms of the pure compounds revealed that because of the presence of the sugar group in its molecule, GlcNAcE3G28 collapsed at a higher surface pressure and occupied a larger molecular area than the PEO-lipid moiety. It was also observed that the presence of the PEO-lipid (E3G28) in the mixtures triggered a strong alteration of both phospholipid pi-A isotherm profiles and surface diffraction spectra, an indication that the disordering of the initially structured phospholipid monolayers took place. Unlike E3G28, GlcNAcE(3)G(28) did not disorganize phospholipid monolayers but generated a partial segregation of the film-forming components. The calculated excess free energies of mixing (Delta G(exc)) for GlcNAcE(3)G(28)-phospholipid mixtures enabled us to predict the stability of such systems.

Domaines: Matière Condensée [cond-mat]

P Dynarowicz-Latka, V Rosilio, P Boullanger, P Fontaine, M Goldmann, et al.. Influence of a neoglycolipid and its PEO-lipid moiety on the organization of phospholipid monolayers. Langmuir, 2005, 21 (25), pp.11941-11948. ⟨10.1021/la051749w⟩. ⟨hal-01290198⟩