Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis - Archive ouverte HAL Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2014

Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis

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Abstract

Melatonin actions are mediated through G protein-coupled transmembrane receptors. Recently, mt1, mt2, and mel1c melatonin receptors were cloned in the Senegalese sole. Here, their day-night and developmental expressions were analyzed by quantitative PCR. These results revealed distinct expression patterns of each receptor through development. mel1c transcripts were more abundant in unfertilized ovulated oocytes and declined during embryonic development. mt1 and mt2 expression was higher at the earliest stages (2–6 days post-fertilization), decreasing before (mt2) or during (mt1) metamorphosis. Only mt1 and mel1c expression exhibited day-night variations, with higher nocturnal mRNA levels. These results suggest different roles and transcriptional regulation of these melatonin receptors during flatfish development and metamorphosis.
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Dates and versions

hal-01328727 , version 1 (08-06-2016)

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Attribution - CC BY 4.0

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Olivier Lan-Chow-Wing, Francesca Confente, Patricia Herrera-Pérez, Esther Isorna, Olvido Chereguini, et al.. Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis. International Journal of Molecular Sciences, 2014, 15 (11), pp.20789-20799. ⟨10.3390/ijms151120789⟩. ⟨hal-01328727⟩
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