Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects
Angela Albi
,
Ofer Pasternak
,
Ludovico Minati
(1)
,
Moira Marizzoni
(2)
,
David Bartres-Faz
(3, 4)
,
Nuria Bargallo
(5)
,
Beatriz Bosch
(4)
,
Paolo Maria Rossini
(6, 7)
,
Camillo Marra
(8)
,
Bernhard Mueller
,
Ute Fiedler
(9)
,
Jens Wiltfang
(9)
,
Luca Roccatagliata
(10, 11)
,
Agnese Picco
(11)
,
Flavio Mariano Nobili
,
Oliver Blin
(12)
,
Julien Sein
(12)
,
Jean-Philippe Ranjeva
(13)
,
Mira Didic
(14)
,
Stephanie Bombois
(15)
,
Renaud Lopes
(16)
,
Regis Bordet
(17)
,
Helene Gros-Dagnac
(18)
,
Pierre Payoux
(19)
,
Giada Zoccatelli
(20)
,
Franco Alessandrini
(20)
,
Alberto Beltramello
(21)
,
Antonio Ferretti
(22)
,
Massimo Caulo
(22)
,
Marco Aiello
(23)
,
Carlo Cavaliere
(23)
,
Andrea Soricelli
(23)
,
Lucilla Parnetti
(24)
,
Roberto Tarducci
(25)
,
Piero Floridi
(25)
,
Magda Tsolaki
(26, 27)
,
Manos Constantinidis
(28)
,
Antonios Drevelegas
(28)
,
Giovanni Frisoni
(2)
,
Jorge Jovicich
(1)
1
UNITN -
Università degli Studi di Trento = University of Trento
2 IRCCS Fatebenefratelli - Brescia
3 Departament de Psiquiatria i Psicobiologia Clinica
4 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
5 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
6 Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA
7 Clinical Neurology
8 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
9 Universität Duisburg-Essen = University of Duisburg-Essen [Essen]
10 Magnetic Resonance Research Centre on Nervous System Diseases [Genova]
11 UniGe - Università degli studi di Genova = University of Genoa
12 INT - Institut de Neurosciences de la Timone
13 CRMBM - Centre de résonance magnétique biologique et médicale
14 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]
15 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
16 JPL - Jet Propulsion Laboratory
17 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
18 ICHN - Imagerie cérébrale et handicaps neurologiques
19 Department of Nuclear Medicine
20 University Hospital of Verona
21 Service of Neuroradiology [borgo trento]
22 Ud'A - Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara]
23 SDN - Istituto di Ricerca Diagnostica e Nucleare
24 Department of Medicine [Perugia, Italy]
25 Perugia General Hospital
26 3rd Department of Neurology
27 Metacohorts Consortium
28 Interbalkan Medical Center of Thessaloniki
2 IRCCS Fatebenefratelli - Brescia
3 Departament de Psiquiatria i Psicobiologia Clinica
4 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
5 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
6 Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA
7 Clinical Neurology
8 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
9 Universität Duisburg-Essen = University of Duisburg-Essen [Essen]
10 Magnetic Resonance Research Centre on Nervous System Diseases [Genova]
11 UniGe - Università degli studi di Genova = University of Genoa
12 INT - Institut de Neurosciences de la Timone
13 CRMBM - Centre de résonance magnétique biologique et médicale
14 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]
15 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
16 JPL - Jet Propulsion Laboratory
17 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
18 ICHN - Imagerie cérébrale et handicaps neurologiques
19 Department of Nuclear Medicine
20 University Hospital of Verona
21 Service of Neuroradiology [borgo trento]
22 Ud'A - Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara]
23 SDN - Istituto di Ricerca Diagnostica e Nucleare
24 Department of Medicine [Perugia, Italy]
25 Perugia General Hospital
26 3rd Department of Neurology
27 Metacohorts Consortium
28 Interbalkan Medical Center of Thessaloniki
Angela Albi
- Fonction : Auteur
Ofer Pasternak
- Fonction : Auteur
Moira Marizzoni
- Fonction : Auteur
- PersonId : 780185
- ORCID : 0000-0003-3749-2988
Bernhard Mueller
- Fonction : Auteur
Jens Wiltfang
- Fonction : Auteur
- PersonId : 776430
- ORCID : 0000-0003-1492-5330
Flavio Mariano Nobili
- Fonction : Auteur
Julien Sein
- Fonction : Auteur
- PersonId : 761846
- ORCID : 0000-0003-1767-5330
Jean-Philippe Ranjeva
- Fonction : Auteur
- PersonId : 757779
- ORCID : 0000-0001-8073-102X
- IdRef : 11434938X
Mira Didic
- Fonction : Auteur
- PersonId : 757436
- ORCID : 0000-0001-7067-536X
Stephanie Bombois
- Fonction : Auteur
- PersonId : 761047
- ORCID : 0000-0003-3117-1833
Pierre Payoux
- Fonction : Auteur
- PersonId : 173132
- IdHAL : pierre-payoux
- ORCID : 0000-0002-1374-1620
- IdRef : 094640149
Roberto Tarducci
- Fonction : Auteur
- PersonId : 780186
- ORCID : 0000-0003-3539-7856
Giovanni Frisoni
- Fonction : Auteur
- PersonId : 768850
- ORCID : 0000-0001-7075-7082
Jorge Jovicich
- Fonction : Auteur
- PersonId : 780184
- ORCID : 0000-0001-9504-7503
Résumé
Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart. We computed the reproducibility of commonly used DTI metrics (FA: fractional anisotropy, MD: mean diffusivity, RD: radial diffusivity, and AXD: axial diffusivity), derived either using a DTI model or a FWE model. The DTI metrics were evaluated over 48 white-matter regions of the JHU-ICBM-DTI-81 white-matter labels atlas, and reproducibility errors were assessed. We found that relative to the DTI model, FWE significantly reduced reproducibility errors in most areas tested. In particular, for the FA and MD metrics, there was an average reduction of approximately 1% in the reproducibility error. The reproducibility scores did not significantly differ across sites. This study shows that FWE improves sensitivity and is thus promising for clinical applications, with the potential to identify more subtle changes. The increased reproducibility allows for smaller sample size or shorter trials in studies evaluating biomarkers of disease progression or treatment effects. Hum Brain Mapp 38:12-26, 2017. (c) 2016 Wiley Periodicals, Inc.