Zika virus and reproduction: facts, questions and current management

Sylvie Epelboin (1) , Emmanuel Dulioust (2) , Loïc Epelboin (3, 4) , Alexandra Benachi (5) , Françoise Merlet (6) , Catherine Patrat (7)

1 Service de Gynécologie - Obstétrique [CHU Bichat]
2 CECOS Paris Cochin - Service d'Histologie-Embryologie, Biologie de la Reproduction
3 UMIT - Unité des Maladies Infectieuses et Tropicales
4 UG - Université de Guyane
5 Service de gynécologie-obstétrique, médecine de la reproduction [Béclère]
6 Agence de la biomédecine [Saint-Denis la Plaine]
7 Epigenèse et développement des mammifères

Epidemiology Diagnosis • Methods • ZIKV in reproductive organs: genital shedding, sexual transmission and impact on fertility ZIKV in the male genital tract: presence and sexual transmission ZIKV and male fertility (animal models) ZIKV in the female genital tract: presence and sexual transmission ZIKV and female fertility (animal models) • Impact of ZIKV infection on pregnancy and offspring (vertical transmission, including hypothesis for the mechanisms of mother-to-child transmission) Maternal infection Pregnancy outcome and offspring malformations Hypotheses for the mechanisms of embryo/foetopathogenic impact of ZIKV • Current management in pregnancy planning and ART in the context of ZIKV epidemics Authorities' plans and strategies at the European and international levels Diagnostic means Pregnancy planning recommendations Guidelines for pregnant women during ZIKV outbreaks ART recommendations • Conclusion

Domaines: Maladies infectieuses; Maladies émergentes; Santé publique et épidémiologie

Sylvie Epelboin, Emmanuel Dulioust, Loïc Epelboin, Alexandra Benachi, Françoise Merlet, et al.. Zika virus and reproduction: facts, questions and current management. Human Reproduction Update, 2017, 23 (6), pp.629 - 645. ⟨10.1093/humupd/dmx024⟩. ⟨hal-01844532⟩