Emergence and Dissemination of Extended‐Spectrum β‐Lactamase–Producing Escherichia coli in the Community: Lessons from the Study of a Remote and Controlled Population

Paul-Louis Woerther (1, 2) , Cécile Angebault (2) , Mathilde Lescat (3) , Etienne Ruppé (4) , David Skurnik (2) , Assiya El Mniai , Olivier Clermont (5) , Hervé Jacquier (5) , Anaelle Da Costa , Magaly Renard , Régis Marc Bettinger , Loïc Epelboin (2) , Claire Dupont (2) , Didier Guillemot (6) , Francois Rousset (7) , Guillaume Arlet (8) , Erick Denamur (9) , Félix Djossou (10) , Antoine Andremont (2)

1 Hôpital Bichat
2 EA3964 - Emergence de la résistance bactérienne in vivo
3 U1139 - Physiopathologie et Pharmacotoxicologie Placentaire Humaine
4 Genomic Research Laboratory [Geneva, Switzerland]
5 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
6 PhEMI - Pharmacoépidémiologie et maladies infectieuses
7 UMR ISEM - Institut des Sciences de l'Evolution de Montpellier
8 UPMC - Université Pierre et Marie Curie - Paris 6
9 EEM - Ecologie et Evolution des Microorganismes
10 Service de médecine interne et maladies tropicales

Intestinal carriage is a key factor in extended-spectrum beta-lactamase (ESBL) infection epidemiology but is difficult to study in open communities. To overcome this problem, we studied a highly stable group of Amerindians for whom we reported an ESBL carriage prevalence of 3.2% in 2001.

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Biologie cellulaire

Paul-Louis Woerther, Cécile Angebault, Mathilde Lescat, Etienne Ruppé, David Skurnik, et al.. Emergence and Dissemination of Extended‐Spectrum β‐Lactamase–Producing Escherichia coli in the Community: Lessons from the Study of a Remote and Controlled Population. Journal of Infectious Diseases, 2010, 202 (4), pp.515 - 523. ⟨10.1086/654883⟩. ⟨hal-01845498⟩