Impact of protease inhibitors on intrahepatic hepatitis C virus viral load. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue AIDS. Official journal of the international AIDS Society Année : 2001

Impact of protease inhibitors on intrahepatic hepatitis C virus viral load.

Résumé

During chronic hepatitis C, hepatitis C virus (HCV) load in plasma was shown to be higher in HIV-co-infected than in immunocompetent patients [1]. The reason for this increased HCV replication is not known. It may be as a result of HIV-induced immune deficiency [2], although some authors did not find any correlation with the CD4 cell count [3]. A direct interaction between HCV and HIV was also hypothesized [4]. Protease inhibitors (PI) used in highly active antiretroviral therapy (HAART) have no HCV reduction effect during the first months of treatment [5-8]. However, a decrease in HCV plasma load was recently described in patients treated with HAART for a year [9,10]. We therefore investigated the potential impact of HAART on intrahepatic HCV load.
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Dates et versions

hal-02014623 , version 1 (11-02-2019)

Identifiants

  • HAL Id : hal-02014623 , version 1
  • PUBMED : 11546953

Citer

Didier Neau, P. Trimoulet, M Winnock, B. Le Bail, Evelyne Schvoerer, et al.. Impact of protease inhibitors on intrahepatic hepatitis C virus viral load.. AIDS. Official journal of the international AIDS Society, 2001, 15 (13), pp.1736-8. ⟨hal-02014623⟩
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