ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

Yuting Ma (1) , Sandy Adjemian , Heng Yang , Joao Paulo Portela Catani (2) , Dalil Hannani (1) , Isabelle Martins , Mickaël Michaud , Oliver Kepp (3) , Abdul Qader Sukkurwala , Erika Vacchelli (4) , Lorenzo Galluzzi (5) , Laurence Zitvogel (1) , Guido Kroemer (6)

1 UMR 1015 - Immunologie des tumeurs et immunothérapie
2 Department of Cell Biology [Boston, MA, USA]
3 Equipe labellisée Ligue contre le cancer - CRC - Inserm U1138 - Apoptose, cancer et immunité
4 Equipe labellisée Ligue contre le cancer - CRC - Inserm U1138 - Apoptose, cancer et immunité
5 IGR - Institut Gustave Roussy
6 U848 - Apoptose, cancer et immunité

Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the proximity of dying cells and promotes their differentiation into mature DCs endowed with the capacity of presenting tumor-associated antigens.

Mots clés: apoptosis; autophagy; calreticulin; CD39; doxorubicin; immunogenic cell death

Domaines: Sciences du Vivant [q-bio]; Immunothérapie; Immunologie; Cancer; Biochimie, Biologie Moléculaire

Yuting Ma, Sandy Adjemian, Heng Yang, Joao Paulo Portela Catani, Dalil Hannani, et al.. ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy. OncoImmunology, 2013, ⟨10.4161/onci.24568⟩. ⟨hal-02047415⟩